STATIN NATION II - Trailer from Justin Smith on Vimeo.
Professor of Vascular Surgery Exposes Cholesterol Myth
STATIN NATION II Trailer1
WORLD PREMIERE - STATIN NATION II, London, Saturday 28th February 2015
I am delighted to announce the world premiere of Statin Nation II.
Duration: 75 minutes
Brief Synopsis: The film is in three parts. Part 1 explains how health authorities around the world have continued to ignore the huge amount of data suggesting that saturated fat and cholesterol do not play a causal role in heart disease. Part 2 examines the current system of using risk factors for disease prevention - which of these risk factors are correct, and can a person be reduced to a short list of numbers? Part 3 moves beyond the system currently used and investigates the real causes of heart disease - proposing for the first time, an alternative model for thinking about the disease.
The film includes interviews with 12 leading experts in this field, and was shot on location in the UK, USA, Denmark, Sweden, France, Lithuania, Australia, Egypt and Japan.
TICKETS: £9.95 per person
Saturday 28th February 6:00pm to 8:00pm
LOCATION:
CHARLOTTE STREET HOTEL, CHARLOTTE STREET, LONDON W1T 1RT.
Did Dan Buettner make a Mistake with his Blue Zones?
Dan Buettner is the author of Blue Zones, a book investigating some of the places in the world where people live the longest. Buetter attempts to unlock the secrets of a long healthy life by looking at the nutrition and lifestyles of people from certain parts of Peru, Italy, the United States and Japan.
The book has considerable merit in that it describes in detail many of the lifestyle habits that have been proven to promote longevity. However, Buettner appears to have made a gross error with regards to the nutritional aspects. In particular, I’m referring to his coverage of the Island of Sardinia, Italy.
Pork Dish Typical of Barbagia Region
The Barbagia Region of Sardinia, and Surrounding Area
The island of Sardinia not only has a large number of people who live to be more than 100, but it is also one of the few places in the world were men live as long as women.
Most regions of Sardinia are associated with incredibly good health, however, the region that has been highlighted as having a particularly long life is called Barbagia.
I have had the privilege of visiting Sardinia, and several other places associated with longevity, during the filming of Statin Nation II. In Sardinia, I found the traditional diet to be in stark contrast to what Buettner describes. He states:
"It’s loaded with homegrown fruits and vegetables such as zucchini, eggplant, tomatoes, and fava beans that may reduce the risk of heart disease and colon cancer. Also on the table: dairy products such as milk from grass-fed sheep and pecorino cheese, which, like fish, contribute protein and omega-3 fatty acids. "
Unfortunately, this common myth about the traditional Sardinian diet has been copied by various websites and commentators.
The cheese part is certainly correct. However, the Barbagia region is for the most part, up in the mountains, away from the coast, and traditionally the people who live there do not eat very much fish. Their diet manly consists of meat. Suckling pig being a particular favorite.
In fact, in 2011, Sardinians called for formal recognition of their diet insisting that “the secret to a long life can be found in their traditional diet of lamb, roast piglet, milk and cheese”
Sardinian Market
I believe the reason why Buettner got it wrong was not because of a deliberate attempt to deceive, but more likely its another example of what happens when we look at the world through the current medical dietary dogma. After all, if you believe that meat and animal fats are bad for you, then by default you wouldn’t list them as contributors to longevity. Which is a shame because people might continue to be misinformed.
Sardinia, along with many other so called paradoxes will be included in Statin Nation II.
Cholesterol Drug CRESTOR No.2 in USA Most Prescribed List
Experts who support the use of statin medications like to keep saying how cheap the drugs are now that Lipitor has gone off patent. Here in the UK, we can often find statements like.... low dose statins only cost £1 a month per patient. Statin supporters have even laughed at the idea that money is the motivation for lowering cholesterol, insisting that the market for statins is not that great.
Well overall, the annual cholesterol-lowering market is still worth US$29 billion. And IMS have just released figures for the most prescribed drugs in the USA.
Between July 2013 and June 2014 more than 22.5 million prescriptions were written for CRESTOR, generating US$5.6 billion for AstraZeneca in one year.
I have commented on CRESTOR before, but this issue is so important, it can’t be mentioned too much.
Crestor has become so popular, because of the JUPITER trial. The results of the JUPITER trial are summarised below in the video excerpt from $TATIN NATION.
An honest assessment of the published trial data shows that Crestor did not provide any meaningful benefit. That's before we even start to look at the adverse effects of Crestor, which included an increase in the risk for type 2 diabetes. However, the situation is even worse than we think.
An article published in the Archives of Internal Medicine in 2010 questioned the validity of the data from the JUPITER trial and raised concerns about the role of the company sponsoring the trial. Another article published in the journal Cardiology in 2011 raised similar concerns .
The leading question is, what the hell happened to evidence based medicine?
For more on this, please see the MedScape article
References:
Ridker, PM et al, for the JUPITER Study Group. Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein. N Engl J Med 2008; 359:2195-207.
de Lorgeril, M et al. Cholesterol lowering, cardiovascular diseases, and the rosuvastatin-JUPITER controversy. A critical reappraisal. Arch Intern Med. 2010; 170:1032-1036.
Serebruany, VL. Extreme all-cause mortality in JUPITER requires reexamination of vital records. Cardiology. 2011; 120:84-8
Breast Cancer Issue - What Your Doctor Doesn’t Know Might Kill You
Many people would have seen the recent media reports claiming that high cholesterol is a risk factor for breast cancer. The suggestion being that statins could be used to prevent breast cancer in the future.
What Dr Potluri of the University of Aston, who did the study, doesn’t know is that researchers from the USA have already studied the effect that statins have on breast cancer.
Researchers from the Fred Hutchinson Cancer Research Center in Washington found that statin use was associated with more than double the risk for breast cancer (both invasive ductal carcinoma and invasive lobular carcinoma).
Nowhere in the media reports was this mentioned. Not even the spokesperson for Breast Cancer Campaign seemed to know about this.
Also, Potluri’s ‘study’ is not published anywhere! It was simply presented at a cardiology conference. So we have no idea what data he analysed or how it was analysed. We know that he used a cholesterol level above 200mg/dl as being high, but we also know that most women in the UK naturally have a cholesterol level above this number anyway and this is perfectly normal for UK women. In any case, what is a cardiologist doing looking at breast cancer data, and presenting this data at a cardiology conference? Surely, he is just fishing for research money.
Dr Potluri is a complete disgrace to his profession and the general public deserve better integrity from the media.
Reference:
Long-Term Statin Use and Risk of Ductal and Lobular Breast Cancer among Women 55 to 74 Years of Age Cancer Epidemiol Biomarkers Prev; 22(9); 1529–37. 2013
Is UK Medicines Licensing Agency a Mouthpiece for Big Pharma?
Here in the UK, the Medicines and Healthcare products Regulatory Agency (MHRA) have recently issued a position statement on their website about statin medications. This has also now been issued as a press release to the media. This statement reads “...people should continue to take their statins as prescribed because their benefits continue to outweigh the risks of any side effects.”
The MHRA is the government organisation that licenses all medications in the UK - it decides if medications work and if they are safe. During the making of $TATIN NATION, I wanted to ask the MHRA about the scientific basis for the use of statins as ‘prevention’. Since none of the clinical trials have shown any life extension when used in primary prevention. However, the MHRA declined my invitation.
This new statement from the MHRA again makes the claim that “statins can save lives”. Therefore, on Tuesday this week I again requested an interview with them. The MHRA replied by asking for more information about the film - which I provided. After that, the line of communication went cold.
It is important to note that although the MHRA is a government organisation, it is not funded by tax payers - the regulation of medications part of the MHRA is funded by the pharmaceutical industry. This can be seen in the FAQs on their website. I think that people should be aware that the organisation that licenses medications in the UK is funded by the pharmaceutical industry. This obvious conflict of interest should be placed at the end of every statement that they publish.
The publication of the MHRA’s press release was prompted by recent media coverage about statin adverse effects and the now famous BMJ article.
The BMJ article was placed in the line of fire by Professor Collins of the pharmaceutical industry funded Oxford group. Professor Collins said the BMJ article exaggerated statin adverse effects. A lot has been written about the BMJ article on the web, however, I feel one additional point is of note that has been missed concerning statins and muscle damage.
A study published in the Journal of the American College of Cardiology found that statins block the adaptive response to exercise.
When we exercise, we stimulate various physiological changes that make our cardiovascular system more efficient - this is one of the main reasons why exercise is a powerful prevention tool for many diseases. However, it has been shown that this adaptation is blocked in people who take statins. In short, statins prevent us from benefiting from exercise. This is just one of the many things that Professor Collins and the MHRA do not want you to know about.
Video Preview Clip for $TATIN NATION II
$TATIN NATION II - First Intro Clip
Towards the end of last year, new cholesterol guidelines were introduced in the US. These guidelines have been shown to be based on flawed ‘evidence’, yet are set to double the number of people who take statin medications.
This issue was covered fairly extensively at the time, however, it is important to keep in mind that despite the criticisms, and the flaws, the guidelines are still being forced through. Doctors will have little choice but to follow them, and millions more people will be exposed to the serious adverse effects of statins.
This video clip includes comments from Dr Malcolm Kendrick, who you probably know already, and Mr Sherif Sultan, who is a leading consultant vascular surgeon, based in Ireland.
To read about Mr Sultan’s credentials, please click here
For Dr Kendrick’s blog, please click here
Mr Sultan’s published critique of statins
To support $TATIN NATION II please click here
It's Not Just Adults that will be Over-Medicated
During the last few days, people within the medical community, the media, and the general public have been astonished to find the level of incompetence associated with the release of the new cholesterol guidelines. It's ironic that we are still referring to them as cholesterol guidelines; the previous approach of 'know your numbers' has now been conveniently changed to 'ignore your numbers'. Which seems to be an attempt to try and put as many adults on statins as possible. It has now been widely reported that the risk calculator (even when it is working correctly) will over-estimate risk and will result in even more over-prescription of statins.
At the same time that this has been taking place, there has been a quieter, perhaps even more alarming development. Whilst the highly complex but considerably flawed algorithm is about to be rolled out on adults, the childhood obesity problem is being used as an excuse to monitor the cholesterol levels of children. We can now see how this is playing out.
Back in 2008, the American Academy of Paediatrics called for the screening of cholesterol levels in children. Reports at the time, referred to children as young as eight being put on statin medications.
Then, in 2011, the National Heart Lung and Blood Institute (NHLBI) released new guidelines that were endorsed by the American Academy of Paediatrics. These recommended universal screening of 9 to 11-year-old children and targeted screening of some subgroups. Yes, another 'expert panel' dictating to doctors.
Not only do these recommendations directly influence how doctors prescribe medications, but the idea also pervades everyone else's consciousness. In particular, we should be concerned about allied health professionals and others who may unintentionally do the wrong thing.
A case in point is the recent announcement that schools in Nixa, Missouri. after receiving part of a $41,916 grant, will now be able to perform cholesterol screenings on 5th graders.
The cholesterol tests will be done under the Cardiac Kids Program, which is put on by CoxHealth and Kohl’s CARDIAC Kids.
Some parts of this program will be beneficial in terms of exercise and healthier eating. Hopefully it will help to reduce the amount of processed food and sugar in the children's diets'. But monitoring, and possibly lowering cholesterol levels from such a young age would cause considerable harm. Since cholesterol is used for:
- the repair of damaged tissues
- a large proportion of the membrane of every cell within the body
- the raw material to make Vitamin D
- the raw material to make all of the steroidal hormones, such as pregnenolone, progesterone, testosterone. oestrogen, and cortisol
- bile acids to digest fats
- key cellular signalling mechanisms (the “intelligence” of the cell)
- the immune system
- the production of new neurons in the developing brain – the highest concentration of cholesterol in the body is found in the brain and the nervous system
There is no indication that the Cardiac Kids Program is funded in anyway by pharmaceutical companies, however, because of the misinformation about cholesterol well meaning people end up doing big pharma's work for them.
Here is the news clip from the local news channel reporting the Cardiac Kids Program
70 Million Americans Set to Take a Statin and the Flawed 'Evidence'
The American National Heart, Lung, and Blood Institute (NHLBI), via the American Heart Association and the American College of Cardiology have just announced a radical change to the way that statins will now be prescribed. Despite the apparent prestige of the organisations disseminating the new guidelines, this marks the beginning of another dark chapter in the history of medicine.
As we all know, the guidelines were previously based on arbitrary cholesterol numbers. This focus on getting millions of peoples' cholesterol levels below an arbitrary threshold has caused a great deal of harm. The situation was already horrific. But now, it is set to get much worse.
Now that the cholesterol thresholds have been driven down, the next attempt to convert even more healthy people into patients is to put less emphasis on the cholesterol numbers and just start medicating almost everyone regardless. It might seem like I'm exaggerating, but I'm not.
Both the previous guidelines and the new ones use a risk scoring system to determine a person's eligibility for statin medication. Various scores are put into the calculator such as cholesterol levels, blood pressure, etc., and a magic number pops out of the algorithm that is supposed to represent a person's risk for having a cardiovascular problem of some kind in the next 10 years.
This model is of course completely flawed. It is based on not only commercial interests but also academic arrogance. The idea that we can precisely determine an individual person's risk with a few selected parameters is nonsense – especially when these parameters ignore many other factors that are known to be major contributors to heart disease.
So, after the announcement, I downloaded the risk calculator and tried it out for myself. I entered different values for the different parameters, however, each time I changed the values a really unexpected risk score was given as the result, and in some cases I radically changed the values and this wasn't reflected in the risk score at all. In the end I gave up with it, thinking that there must be something wrong with my version of microsoft excel or something. Then, just before posting this blog entry I went back to the website and found this message:
It seems that I wasn't the only person having problems with it! However, putting this huge issue to one side, and assuming the largest health authorities in the world can eventually fix the spreadsheet, the other major problem is the lowering of the risk threshold that is now going to be used.
Previously, anyone who comes out of the algorithm with a 10 year risk of 20% or more was considered eligible for statin medication. Now, with the new guidelines, you only need to have a 10 year risk of 7.5% or more in order to get a statin. In fact, in the report detailing the guidelines, the expert panel even suggest that people below the 7.5% risk level could also be eligible for statins.
There have also been some changes to the way that the calculation itself is done. All things considered, it is probably fair to say that (once the spreadsheet is fixed) the new guidelines double the number of people who are eligible for statin medications.
According to the BBC, Dr George Mensah, of the American Heart Association, told the Associated Press news agency that the guidelines were based on solid evidence.
Considering the fact that statins do not extend life expectancy when used for prevention it is pretty impossible to believe Dr Mensah.
We already know that the previous guidelines have led to the mass over-prescription of statins for people who, all the clinical data shows, will not benefit. If this was not bad enough, the harm that has been caused is now set to double. And this is thoroughly disgusting.
So what evidence is Dr Mensah referring to? In the report, the expert committee state the following:
“the Cochrane meta-analysis, as well as a meta-analysis by the Cholesterol Treatment Trialists , confirms that primary prevention with statins reduces total mortality”
A closer examination of the data from the most recent Cochrane review was completed by Dr Uffe Ravnskov earlier this year. Dr Ravnskov stated:
“without statins your chance to be alive after a few years without treatment is 94.8 %, but if you take a statin every day you can increase your chance to 95.6. ... In the control group 5.17 % had died, and in the treatment group 4.41% - a difference of 0.76 %”
In addition, a previous Cochrane meta-analysis did not support the use of statins for prevention. The researchers stated the potential benefit was so small that it could have been down to chance. In this previous Cochrane meta-analysis they also highlighted the fact that around half of the clinical trials they included did not report on the adverse effects of the statin.
The other piece of 'evidence' that is quoted in the report (the Cholesterol Treatment Trialists Study) is even less convincing. The researchers in this case did not publish the data for total mortality in the main report – in order to see that data you have to look in the supplementary appendix.
The table below is copied from the supplementary appendix published alongside the main trial report. It is immediately obvious why the researchers chose not to make a song and dance about these results. Since it is clear that the statin only reduced the risk of dying from any cause by 0.07%.
And what about all of the other studies that have shown statins have no impact on life expectancy? Such as the meta-analysis completed by Professor Kausik Ray, published in the Archives of Internal Medicine.
Even if we can trust all of the data currently published by the drugs companies about their own products, the absolute best case scenario is that statins (when used for prevention) have considerably less than a 1% benefit and a 20% risk of significant adverse effects.
When considering the adverse effects of statins, the expert panel should also have been aware of the more than 300 adverse effects of statins that have now been documented. As reported by GreenMedInfo.com after an extensive review of the medical literature.
This Pretty Much Sums Up the Broken Medical System
The cholesterol-lowering medication Crestor (rosuvastatin) was the most prescribed medication in the United States during the last 12 months. As reported by Medscape Medical News in response to research completed by IMS Health.
Crestor topped the list of the most prescribed medications, with 23.7 million prescriptions. In terms of sales, Crestor was 5th on the list with total sales of 5.3 billion USD.
One of the reasons why Crestor has become so popular, is the JUPITER trial. In 2008, pharmaceutical companies and much of the world's media trumpeted the results of the JUPITER trial, which involved the use of Crestor for people with elevated levels of C-reactive Protein (a marker of systemic inflammation).
The results of the JUPITER trial are summarised below in the video excerpt from $TATIN NATION. An honest assessment of the published trial data shows that Crestor did not provide any meaningful benefit. That's before we even start to look at the adverse effects of Crestor, which included an increase in the risk for type 2 diabetes. However, the situation is even worse than we think.
An article published in the Archives of Internal Medicine in 2010 questioned the validity of the data from the JUPITER trial and raised concerns about the role of the company sponsoring the trial. Another article published in the journal Cardiology in 2011 raised similar concerns . Unfortunately, these critical papers were not given the same prominence within the medical journals as was given to the JUPITER trial results and were not mentioned in the mainstream media at all.
So, we have a situation where the most prescribed medication in the United States is causing more harm than good, and is being prescribed on heavily spun, highly questionable data. The questioning of the trial data has been ignored and millions of people just keep taking the medication.
References:
Ridker, PM et al, for the JUPITER Study Group. Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein. N Engl J Med 2008; 359:2195-207.
de Lorgeril, M et al. Cholesterol lowering, cardiovascular diseases, and the rosuvastatin-JUPITER controversy. A critical reappraisal. Arch Intern Med. 2010; 170:1032-1036.
Serebruany, VL. Extreme all-cause mortality in JUPITER requires reexamination of vital records. Cardiology. 2011; 120:84-
ABC TV Australia Plagiarised Independent Filmmaker for 'their' Cholesterol and Satins Program.
Although I am delighted that ABC went ahead with their broadcast about statins, and even more delighted to see that it has cooked up a real stir in Australia, I feel I have to inform people of the extent to which ABC Catalyst plagiarised $TATIN NATION without my consent and without informing me. I think the video clip below makes this clear.
Cholesterol, statins, and heart disease is of course a gigantic subject and there are a thousand different ways that a TV program could have been constructed on this issue, and with many possible different angles. After watching part 2 of the Catalyst program, it is clear that large sections of $TATIN NATION have been copied without consent, and no appropriate credit given.
$TATIN NATION was listed in the 'Thanks To' section of the credits on the second program, but I strongly feel that more credit should have been given. Giving appropriate credit to $TATIN NATION would have helped greatly with my efforts to globally create awareness about this issue.
I am an independent filmmaker with very limited resources, I made $TATIN NATION through sheer hard work and determination, working 7 days a week for almost 2 years. As well as 7 years of research. Yet the Catalyst program chose the easy option of copying my original ideas, the structure and specific content. All without informing me.
Plagiarising an independent filmmaker's work like this is unethical.
$TATIN NATION is not just a film but also a global outreach campaign. I would have been delighted to have worked closely with ABC Catalyst on this film, but they chose to try and pass it off as their own original investigation.
I also have an obligation to the other professionals who helped me make $TATIN NATION. I was able to work with very experienced people, and I went to considerable effort to make a professional film – all of my team deserve appropriate credit for their work.
Someone Should Educate this 'Expert'!
Its just a few hours until the broadcast of ABC's TV program about statins. After part one of the two-part series was shown, some of the Australian health authorities asked ABC not to broadcast the program. Like thousands of other people, I am hoping the program doesn't pull any punches and shows the dreadful deception behind statin medications.
Professor Emily Banks, speaking for the Advisory Committee on the Safety of Medicines, has publicly stated that people are likely to die if they stop taking their statin as a result of the program.
Those of us who follow this subject closely will instantly see the irony of an 'expert' on medicine safety supporting the use of statins. I get so tired of these 'experts' spouting absolute nonsense without any scientific evidence to back up their comments.
For example, Professor Banks should be pointed in the direction of this Japanese study. The researchers found that cholesterol reduction leads to an increase in total mortality. In fact, the people in the lowest cholesterol group had more than double the mortality rate of those in the highest cholesterol group.
Researchers in the Netherlands also found that life expectancy increases when cholesterol levels are higher. Those with higher cholesterol levels appeared to be better protected from cancer and infection.
Further evidence that higher cholesterol is protective was established by Professor Jacobs and Dr. Carlos Iribarren who followed more than 100,000 healthy individuals in the San Francisco area for fifteen years. Low cholesterol was associated with a higher rate of infectious disease.
Another study, looked at cholesterol levels and death rates in more than 3500 elderly Japanese/American men over a twenty year period. The authors of this paper confirmed an increase in death rates in people with low blood cholesterol levels. The authors went on to say that not only do these results provide more evidence that low cholesterol in the elderly is associated with an increased risk of death, but they also suggest that people who have low cholesterol maintained over a twenty year period have the worst outlook for mortality.
The ABC program airs at 8pm in Australia, however, it should be available shortly after it airs from the link below:
http://www.abc.net.au/catalyst/
Australian National TV Helps to Expose the Cholesterol Myths (Copying Several Parts of $TATIN NATION)
ABC's TV show Catalyst has just broadcast the first part of a two-part programme on saturated fat and cholesterol. The programme, presented by Dr Maryanne Demasi, is similar in several ways to $TATIN NATION (in structure, style of music, use of imagery, and some specific content).
It is immensely satisfying to see a national broadcaster finally picking up this issue and to see the message reaching a wider audience!
Towards the end of last year I corresponded with Dr Maryanne Demasi and she purchased a copy of $TATIN NATION. However, since then I had not received any further correspondance and I was not informed that ABC planned to make their own programme. I did try to follow-up with Dr Maryanne Demasi earlier this year, but I didn't receive a response. I found out about this programme this morning (after it was aired) from a post on twitter. Unfortunately, although $TATIN NATION has obviously influenced the ABC programme, ABC have not acknowledged this in their credits.
This is an example of the cut-throat world of corporate media and is yet another reason why independent film production is very close to impossible to sustain.
The ABC programme is very good, and I highly recommend everyone to watch it. However, what is now needed is a proper explanation for the real causes of heart disease. I have been researching this in much more detail during the last few months and have become aware of some surprising results.
We already know that heart disease is an inflammatory condition and that excess sugar consumption is a major factor, however, there is certainly more to it than that. I believe that we now have a coherent alternative explanation for the real causes of heart disease. This new theory, in some ways, unites the different nutritional schools of thought.
In addition, I want to look at the other so called risk factors for heart disease and the other common medications that people take for 'prevention'.
For more details of $TATIN NATION part 2, please click here:
http://www.statinnation.net/statin-nation-ii/
You can watch the ABC programme directly from their website at the link below, and they also have a number of useful free downloads associated with the programme:
http://www.abc.net.au/catalyst/heartofthematter/
British National Press Does it Again with Extremely Misleading Article
This weekend, at least 3 national newspapers here in the UK (the Daily Mail, the Telegraph, and the Mirror) printed an article suggesting that cholesterol-lowering statin medications had led to a 40% reduction in strokes in Britain.
Based on what was written in these newspapers, it was initially a little time consuming to find the actual published research they are referring to – this is because their description of the stroke reduction being attributed to statins didn't match any of the published studies in the medical literature. As far as I can establish, they are referring to this study:
Although the 3 newspapers state that statins have been the main factor, there is no evidence of this whatsoever in the above study. There is only one reference to statins in the study itself, which reads:
“There are limitations in our study. We do not have cholesterol/pathology data in our stroke register but we do have use of statins. “
That's it. There is no further mention of statins or any mention of the impact statins might or might not have had.
So, the national press has just plucked this headline out of thin air. Or maybe this article came about as a result of a press release from the drugs companies or an organisation which supports the drugs companies? Who knows? Wherever it came from, it has deeply misled the general public.
This is not the first time this has happened, I wrote about a similar case at the end of last year.
Its no wonder that many people are confused about this issue.